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The Powerful Benefits of 5-Amino-1MQ for Women’s Bodies and Wellness

5-Amino-1MQ is a peptide that may enhance energy, promote healthy aging, and boost fat metabolism in women by inhibiting NNMT and increasing NAD⁺ levels.

Published: October 15, 2025

5-Amino-1MQ is a peptide that could unlock the health and body support women have been searching for. Some women struggle with low energy, slow metabolism, and concerns about aging. 5-Amino-1MQ has shown potential in enhancing energy, promoting healthy aging, and boosting fat metabolism, all in a clinically safe and cost-effective way.

The effects of 5-Amino-1MQ are linked to its ability to block Nicotinamide N-methyltransferase (NNMT)1, an enzyme involved in metabolism and aging. By inhibiting NNMT, the body maintains higher NAD⁺ levels, which in turn activate SIRT1, a longevity-associated gene, which may improve mitochondrial activity, fat oxidation, insulin sensitivity, and by overall energy balance.

Experiencing stubborn weight gain, lack of energy, or age-related changes? For many women, 5-Amino-1MQ could be a game-changer. At Vita Bella, we provide high-quality peptides that are safe, cost-effective, and trusted by healthcare professionals.

Benefits of 5-Amino-1MQ for Women

5-Amino-1MQ’s potential benefits are particularly relevant to women’s health. Its role as an NNMT inhibitor highlights effects on metabolic function, endurance, and healthy aging. Research also points to potential improvements in:

Let’s discuss proposed mechanisms of action to allow for a deeper understanding of its benefits. 

1. Weight Management:

By blocking NNMT, 5-Amino-1MQ promotes mitochondrial fat oxidation3 and supports impaired metabolism. This preserves nicotinamide for NAD⁺ production, improving energy and fat-burning efficiency.

A study shows4 that 5-Amino-1MQ prevents diet-induced obesity and reduces fat mass without affecting other enzymes in NAD⁺ salvage pathways. Female mice on a high-fat diet who received 5-Amino-1MQ demonstrated significantly reduced body weight, adipose tissue mass, and insulin levels.

2. Energy and Fitness:

5-Amino-1MQ boosts intracellular NAD⁺ levels5 and enhances mitochondrial function, supporting sustained energy production.

The benefits of NAD⁺ metabolism may be even greater. They also have an impact on NAMPT levels6, which fluctuate to meet cellular NAD+ demand.  Thus, following just three weeks of exercise training, sedentary non-obese participants' NAMPT protein levels rose by 127% in an exercise intervention trial.

3. Healthy Aging

An essential coenzyme7 in the metabolism of cellular energy is NAD+. Essential metabolic can be impaired as a result of decreased mitochondrial activity brought on by low NAD+ levels.

NAD⁺ plays a central role in cellular repair and mitochondrial function. Low NAD⁺ levels are linked to oxidative stress, free radical damage, and age-related diseases8 such as:

  • Diabetes

  • Neurodegenerative disorders

  • Vascular damage

  • Accelerated aging

By restoring NAD⁺, 5-Amino-1MQ helps reduce oxidative stress, protecting cells, DNA, and proteins from damage.

4. Muscle Preservation

Sarcopenia (age-related muscle loss) often leads to weakness and reduced recovery. NNMT inhibitors like 5-Amino-1MQ support muscle strength9, endurance, and regeneration.

In one study 10, elderly mice treated with 5-Amino-1MQ showed:

  • ~40% stronger grip strength in sedentary conditions

  • ~20% improvement with exercise

  • ~60% boost when combined with exercise + therapy

This suggests powerful benefits for maintaining strength and resilience with age.

5. Cognitive Support 

Higher NAD⁺ levels activate sirtuins10 (SIRT1, SIRT3), which protect brain cells by reducing oxidative stress, supporting DNA repair, and improving mitochondrial health. Their are several proposed benefits of these changes which include the following:

  • Cognitive clarity

  • Neuroprotection

  • Reduced risk of neurodegeneration

How 5-Amino-1MQ Helps Women Feel Stronger and Healthier?

5-Amino-1MQ offers more than just weight management, it supports overall fitness, healthy aging, and cognitive health through its unique impact on cellular metabolism. Backed by scientific insights into NAD+ pathways and sirtuin activation, here’s a breakdown of its most important benefits.

Take Charge of Your Health weight management with Vita Bella’s 5-Amino-1MQ

Struggling with stubborn weight, low energy, or the effects of aging? You don’t have to let these challenges define your journey. At Vita Bella, we specialize in premium, research-backed peptides like 5-Amino-1MQ, designed to support women’s metabolism, vitality, and healthy aging. By boosting cellular energy and promoting fat metabolism, 5-Amino-1MQ helps you feel stronger, more confident, and in control of your wellness.

FAQs

What is 5-Amino-1MQ and how does it work for women?

5-Amino-1MQ is a small molecule that works by inhibiting NNMT (Nicotinamide N-methyltransferase), an enzyme that reduces NAD⁺ levels in the body. By blocking NNMT, 5-Amino-1MQ helps preserve NAD⁺, which supports metabolism, energy production, and cellular repair. For women, this can contribute to better weight management, and healthy aging support.

Is 5-Amino-1MQ safe for women to use?

Research on 5-Amino-1MQ is still emerging, but preclinical studies suggest it has a good safety profile when used properly. Since it influences cellular metabolism, women should consult a healthcare professional before starting supplementation, especially if they are pregnant, nursing, or managing medical conditions.

What benefits can women expect from 5-Amino-1MQ supplementation?

Women using 5-Amino-1MQ experience certain benefits such as improved weight management by promoting fat metabolism, higher energy levels through NAD⁺ support, muscle preservation and recovery, especially in active or fitness-focused women, and cognitive clarity and focus, linked to better mitochondrial health.

References:

  1. Dimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep. 2024 Jul 5;14(1):15554. doi: 10.1038/s41598-024-66034-9. PMID: 38969654; PMCID: PMC11226645.

  2. Unni SN, Lakshman LR, Vaidyanathan K, Subhakumari KN, Menon NL. Alterations in the levels of plasma amino acids in polycystic ovary syndrome--A pilot study. Indian J Med Res. 2015 Nov;142(5):549-54. doi: 10.4103/0971-5916.171281. PMID: 26658589; PMCID: PMC4743341.

  3. Liu JR, Deng ZH, Zhu XJ, Zeng YR, Guan XX, Li JH. Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes. Biomed Res Int. 2021 Jul 27;2021:9924314. doi: 10.1155/2021/9924314. PMID: 34368359; PMCID: PMC8337113.

  4. Sebastian Brachs, James Polack, Maria Brachs, Kerstin Jahn-Hofmann, Ralf Elvert, Anja Pfenninger, Felix Bärenz, Daniel Margerie, Knut Mai, Joachim Spranger, Aimo Kannt; Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance. Diabetes 1 March 2019; 68 (3): 527–542. https://doi.org/10.2337/db18-0780

  5. Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jan;147:141-152. doi: 10.1016/j.bcp.2017.11.007. Epub 2017 Nov 15. PMID: 29155147; PMCID: PMC5826726.

  6. Conlon N, Ford D. A systems-approach to NAD+ restoration. Biochem Pharmacol. 2022 Apr;198:114946. doi: 10.1016/j.bcp.2022.114946. Epub 2022 Feb 5. PMID: 35134387.

  7. Klimova, N., & Kristian, T. (2019). Multi-targeted effect of nicotinamide mononucleotide on brain bioenergetic metabolism. Neurochemical Research, 44(10), 2280-2287.

  8. Maiese, K. (2023). The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk. Frontiers in immunology, 14, 1273570.

  9. Dimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep. 2024 Jul 5;14(1):15554. doi: 10.1038/s41598-024-66034-9. PMID: 38969654; PMCID: PMC11226645.

  10. Sun WD, Zhu XJ, Li JJ, Mei YZ, Li WS, Li JH. Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome. Front Pharmacol. 2024 Jun 11;15:1410479. doi: 10.3389/fphar.2024.1410479. PMID: 38919254; PMCID: PMC11196770.

  11. Dimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep. 2024 Jul 5;14(1):15554. doi: 10.1038/s41598-024-66034-9. PMID: 38969654; PMCID: PMC11226645.

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