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MK-677 (Ibutamoren)

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MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren, is a potent, orally active growth hormone secretagogue.

✓
Natural growth hormone release
✓
Increased Hunger
✓
Improved body composition
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Enhanced recovery, healing and sleep quality

from $90/mo.*

*with Membership, consult, and provider approval

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⚠️ Currently Not Available in Kentucky, Louisiana, Ohio & Virginia
CLINICALLY-PROVEN RESULTS
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The science behind
MK-677 (Ibutamoren)

MK-677 (ibutamoren) physiologically works as a potent, orally active growth hormone secretagogue by mimicking the action of ghrelin, the "hunger hormone," at the ghrelin receptor (GHSR-1a) in the brain, particularly in the pituitary gland and hypothalamus. This agonistic action leads to a significant and sustained increase in the pulsatile release of endogenous growth hormone (GH) from the pituitary, as shown in numerous PubMed studies. For instance, research by Chapman et al. (1996) and Thorner et al. (1999) demonstrated that MK-677 consistently elevated 24-hour mean GH concentrations in humans, often restoring levels seen in younger adults. This surge in GH, in turn, stimulates the liver and other tissues to produce insulin-like growth factor 1 (IGF-1), which is a primary mediator of many of GH's anabolic and metabolic effects. Studies in elderly adults, such as those by Copinschi et al. (2000), have confirmed that MK-677 increases both GH and IGF-1 levels, correlating with beneficial changes in body composition and bone turnover markers. Unlike direct GH administration, MK-677 promotes the body's natural GH secretion pattern and generally does not significantly alter other pituitary hormones like cortisol or prolactin at therapeutic doses, making it a more selective modulator of the somatotropic axis.
Science behind MK-677 (Ibutamoren)

The mechanism of
MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren, is a powerful pill that essentially tells your body to make more of its own growth hormone (GH). It does this by acting like a natural hunger hormone called ghrelin.

MK-677 attaches to specific "ghrelin receptors" in your brain, especially in areas like the pituitary gland, which is responsible for releasing GH. When it binds there, it signals your pituitary to release more GH.

Taking MK-677 can lead to consistently higher GH levels throughout the day, often bringing them back to what you'd see in younger adults. This increased GH then prompts your liver and other tissues to produce more IGF-1 (Insulin-like Growth Factor 1). IGF-1 is super important because it's what actually carries out many of GH's benefits, like building muscle and helping with metabolism.

Unlike simply injecting GH, MK-677 encourages your body to release GH in its natural, on-and-off bursts. This is key because it generally means fewer side effects and less interference with other hormones like cortisol (your stress hormone) or prolactin, making it a more targeted way to boost your body's natural growth hormone system.
INGREDIENTS
MK-677 (Ibutamoren)
BENEFITS
Increased hunger: Acting like a naturally occurring hunger hormone, this can stimulate the desire for food for those looking to consume more food.

Increased Lean Muscle Mass: By boosting GH, these peptides support muscle growth and repair, leading to increased lean muscle mass and strength gains.
  • ✔Enhanced Fat Loss: They can accelerate lipolysis (the breakdown of fat cells) and improve metabolism, helping to reduce body fat, especially in stubborn areas, and leading to a more sculpted physique.
  • ✔Skin and Hair Health: Increased collagen production, often associated with higher GH levels, can lead to improved skin elasticity, reduced wrinkles, and healthier hair and nails.
  • ✔Bone Density: Growth hormone plays a role in bone mineral density, potentially contributing to stronger bones.
Doctors Say:
Physicians reach for MK-677 (Ibutamoren) when they are looking for a growth hormone secretagogue that works systemically but also looking for an easier delivery method such as a capsule vs injectables. MK-677 is also used for those individuals who are looking to address lack of hunger or underconsumption of calories.
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  • Daily
  • Oral Capsule
  • 10mg, 25mg
60%
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NAD+Med / IV Clinics
25mg injection$59 per shot$7 per shot*
1000mg (40 treatments)$2,360$249 (supplies included)**
Private At-Home UseNoYes
US FDA-Inspected PharmacyNoYes
*with Membership
**1000mg vial (40 × 25mg injections)
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